658 Works

Effect of changed source/sink relations on proteolytic activities and on nitrogen mobilization in field-grown wheat (Triticum aestivum L.)

Urs Feller
Nitrogen mobilization and the pattern of proteolytic enzymes were investigated in leaves and glumes of field-grown winter wheat (Triticum aestivum L.) during maturation. Source/sink relations were changed by removal of the ear, the flag leaf or the lower leaves shortly after anthesis. Removal of the ear was most effective, resulting in delayed senescence of the flag leaf with the chlorophyll, aminopeptidase and carboxypeptidase activities remaining high in contrast to the control, whereas neutral endopeptidase activity...

Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics.

Brett Mc Kinnon, Konstantinos Nirgianakis, Michael Mueller, Vida Kocbek & Nick A. Bersinger
BACKGROUND Endometriosis, the growth of endometrial tissue outside the uterine cavity, is associated with chronic pelvic pain, subfertility and an increased risk of ovarian cancer. Current treatments include the surgical removal of the lesions or the induction of a hypoestrogenic state. However, a reappearance of the lesion after surgery is common and a hypoestrogenic state is less than optimal for women of reproductive age. Additional approaches are required. Endometriosis lesions exist in a unique microenvironment...


Affiliation Bd. 81, Nr. 2 (2017)

Corpus-based analysis of the collocational profiles of the terms denoting the mentally challenged

Liana Markelova
The present study aims to trace the evolution of public attitude towards the mentally challenged by means of the corpus-based analysis. The raw data comes from the two of the BYU corpora: Global Web-Based English (GloWbE) and Corpus of Historical American English (COHA). The former is comprised of 1.8 million web pages from 20 English-speaking countries (Davies/Fuchs 2015: 1) and provides an opportunity to research at a cross-cultural level, whereas the latter, containing 400 million...

A dual PCR-based sequencing approach for the identification and discrimination of Echinococcus and Taenia taxa

Norbert Müller, Markus Spiliotis, Bruno Gottstein, Adriano Casulli, Irina Marinova, Francesca Gori, Amani Hizem, Ghalia Boubaker, Luis Enrique Jerez Puebla & Hamouda Babba
Reliable and rapid molecular tools for the genetic identification and differentiation of Echinococcus species and/or genotypes are crucial for studying spatial and temporal transmission dynamics. Here, we describe a novel dual PCR targeting regions in the small (rrnS) and large (rrnL) subunits of mitochondrial ribosomal RNA (rRNA) genes, which enables (i) the specific identification of species and genotypes of Echinococcus (rrnS + L-PCR) and/or (ii) the identification of a range of taeniid cestodes, including different...

Instability of the hip after anatomical re-alignment in patients with a slipped capital femoral epiphysis

Reinhold Ganz, A. Aprato, Theddy Slongo, Michael Leunig & A. Massé

Sozialgeschichte der Zuwanderung in die Stadt Bern 1850-1914

Christian Lüthi

Modifying the Glycome in Pigs for Xenotransplantation.

Robert Rieben & Peter J Cowan

Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs.

Robert Rieben, Ahmed Aziz Khattab, Pranitha Jayadev Kamat, Stephan Christen, Anjan Bongoni, Bernhard Meier & Stijn Vandenberghe
Calcium and iron overload participate in the mechanisms of ischemia/reperfusion (I/R) injury during myocardial infarction (MI). Calcium overload induces cardiomyocyte death by hypercontraction, while iron catalyses generation of reactive oxygen species (ROS). We therefore hypothesized that dexrazoxane, an intracellular metal chelator, would attenuate I/R injury. MI was induced in pigs by occlusion of the left anterior descending artery for 1 hour followed by 2 hours reperfusion. Thirty minutes before reperfusion either 5 mg/ml dexrazoxane (n...

Cervical vertebrae maturation method and craniofacial growth.

Nikolaos Pandis, Christos Katsaros & Piotr Fudalej

Gewalt der Sprache: Lexikalische Abwertung als (Ab)Bild einer Sprachgemeinschaft

Marija Brala-Vukanović & Aneta Stojić
The focus of this paper is on pejoratives, i. e. on lexical units of the negative evaluative type. Departing from the assumption that the study of negative evaluation offers an insight into hu-man nature, we shall here analyse the process of negative evaluation (the process of pejoriza-tion), as well as the result of that process (pejoratives themselves). The analysis is conducted on currently available research – both traditional and cognitive linguistic – as well as...

Übersetzung pejorativer Personenbezeichnungen

Anita Pavić Pintarić
This paper investigates the translation of pejoratives referring to persons. The corpus is comprised of literary dialogues in the collection of short stories about the First World War by Miroslav Krleža. The dialogues describe the relationship between officers and soldiers. Soldiers are not well prepared for the war and are the trigger of officers’ anger. Therefore, the dialogues are rich with emotionally loaded outbursts resulting in swearwords. Swearwords relate to the intellect and skills of...

Vertical mobility around the high-alpine Schnidejoch Pass. Indications of Neolithic and Bronze Age pastoralism in the Swiss Alps from paleoecological and archaeological sources.

Albert Hafner & Christoph Schwörer
Since 2003 a melting ice field on the Schnidejoch Pass (2756 m a.s.l.) has yielded several hundred objects from the Neolithic period, the Bronze and Iron Ages and from Roman and early medieval times. The oldest finds date from the beginning of the 5th millennium BC, whilst the most recent artefacts date from around AD 1000. Most of the objects belong to the Neolithic period and the Bronze Age and are of organic origin. A...

Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies.

H Wu, E Sadler, P Coppo, M Matsumoto, R Sarode, M Scully, J De La Rubia, S Cataland, Johanna Anna Kremer Hovinga, K Pavenski, K D Friedman & Bernhard Lämmle
BACKGROUND Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are two important acute conditions to diagnose. Thrombotic Microangiopathy is a broad pathophysiological process that leads to microangiopathic hemolytic anemia, thrombocytopenia and involves capillary and small vessel platelet aggregates. The most common cause being disseminated intravascular coagulation (DIC), which may be differentiated by abnormal coagulation. Clinically, a number of conditions present with microangiopathic hemolytic anemia and thrombocytopenia (MAHAT), including cancer, infection, transplantation, drugs, autoimmune disease...

EURObservational Research Programme: the Chronic Ischaemic Cardiovascular Disease Registry: Pilot phase (CICD-PILOT).

Wojciech Majda, Serban Balanescu, Zoran Olivari, Marco Valgimigli, Alberto Cremonesi, Serge Kownator, Rimvydas Slapikas, Francesco Cosentino, Luigi Tavazzi, Constantinos Tsioufis, Philippe Gabriel Steg, Eric Van Belle, Miguel Mendes, Roberto Ferrari, Franz Weidinger, Michel Komajda, Evgeny Vladimirovich Shlyakhto, Cécile Laroche, Harald Rittger, Hanna Szwed, Iveta Mintale, Mathieu Kerneis & Aldo Pietro Maggioni
AIMS Chronic ischaemic cardiovascular disease (CICD) is a major cause of mortality and morbidity worldwide. The primary objective of the CICD-Pilot registry was to describe the clinical characteristics and management modalities across Europe in a broad spectrum of patients with CICD. METHODS AND RESULTS The CICD-Pilot registry is an international prospective observational longitudinal registry, conducted in 100 centres from 10 countries selected to reflect the diversity of health systems and care attitudes across Europe. From...

Implementation of subjective cognitive decline criteria in research studies

Rachel Buckley, Michael Ewers, Colette M Smart, Beth E Snitz, Rebecca Amariglio, Frank Jessen, Laura A Rabin, Sietske Sikkes, Michael Wagner, Stefan Klöppel, Harald Hampel, José L Molinuevo, Reisa Sperling, Lorena Rami, Bruno Dubois, Barry Reisberg, Wiesje M Van Der Flier, Andrew J Saykin & Kathryn A Ellis
INTRODUCTION Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. METHODS Members of the SCD-I met to identify and agree on topics relevant to SCD...

Reading English-Language Haiku: Processes of Meaning Construction Revealed by Eye Movements

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In the present study, poets and cognitive scientists came together to investigate the construction of meaning in the process of reading normative, 3-line English-language haiku (ELH), as found in leading ELH journals. The particular haiku which we presented to our readers consisted of two semantically separable parts, or images, that were set in a ‘tense’ relationship by the poet. In our sample of poems, the division, or cut, between the two parts was positioned either...

Gaze Strategies in skateboard trick jumps: Spatiotemporal constraints in complex locomotion

André Klostermann & Philip Küng
Purpose. This study aimed to further the knowledge on gaze behavior in locomotion by stud-ying gaze strategies in skateboard jumps of different difficulty that had to be performed ei-ther with or without an obstacle. Method. Nine experienced skateboarders performed “Ollie” and “Kickflip” jumps over either an obstacle or over plane surface. The stable gaze at five different areas of interest was calculated regarding its relative duration as well as its temporal order. Results. Over the...

Diversity and dynamics of rare and of resident bacterial populations in coastal sands

Christopher Quince, Susan M Huse, Angélique Gobet, Antje Boetius, Simone I Böer, Alban Nicolas Ramette, Mitchell L Sogin & Justus E E Van Beusekom

Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation.

Anjan Bongoni, David Ayares, Robert Rieben, Nikolai Klymiuk, Eckhard Wolf & Peter J Cowan
BACKGROUND Transgenic expression of human thrombomodulin (hTBM), which has the potential to solve the problem of coagulation dysregulation in pig-to-primate xenotransplantation, may have additional benefits by neutralizing the proinflammatory cytokine high-mobility group box 1 (HMGB1). The aim of this study was to investigate HMGB1-mediated effects on porcine aortic endothelial cells (PAEC) from wild-type (WT) and hTBM transgenic pigs. METHODS Porcine aortic endothelial cells were treated with HMGB1, human (h)TNFα or lipopolysaccharide (LPS). Procoagulant and proinflammatory...

Nuss procedure for pectus excavatum in adults: long-term results in a prospective observational study.

Beatrix Hoksch, Philippe Bernard Vollmar, Fabien Praz, Ralph Schmid & Gregor Kocher
OBJECTIVES Since the end of the 1990s, the management of pectus excavatum has undergone major changes. The Nuss procedure (pectus bar) has been the method of choice for patients with pectus excavatum at Bern University Hospital for over a decade. The current study will describe our experiences, with a particular focus on long-term results in adults. METHODS The prospective observational study began in autumn 2002. The Haller index was used to quantify pectus excavatum severity....

Transfer hydrogenation with abnormal dicarbene rhodium( iii ) complexes containing ancillary and modular poly-pyridine ligands

Philipp Melle, Robert A. Gossage, Helge Müller-Bunz, Martin Albrecht & Kevin Farrell
Treatment of an abnormal dicarbene ligated rhodium(III) dimer with 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen) or 2,2′:6′,2′′-terpyridine (terpy) results in coordination of the N-donor ligands and concomitant cleavage of the dimeric structure. Depending on the denticity of the pyridyl ligand, this situation retains one (L = terpy) or two (L = bipy, phen) flexible sites for substrate coordination. In the case of the bipy complexes, modification of the electron density at Rh, without directly affecting the steric...

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