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Rozenn Béguin Botokro
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Conception d’un outil d’évaluation du fonctionnement quotidien pour les personnes présentant un trouble de personnalité limite, le Fonctionnement au quotidien avec un trouble de la personnalité Borderline (FAB)

Pierre David, Richard Boyer, Nadine Larivière, Julie J. Desrosiers, Félix Antoine Bérubé, Johanne Desrosiers & Frédéric Pérusse
Introduction. Le trouble de la personnalité limite (TPL) entraîne des conséquences majeures sur le quotidien des personnes qui en sont affectées. Sans une iden­ti­fi­cation rigoureuse des sphères fonctionnelles déficientes, la réadaptation peut s’avé­rer imprécise. Les mesures actuelles du fonctionnement utilisées auprès de la cli­en­tèle ayant un TPL sont générales et ne couvrent pas toutes les sphères déficitaires pour ce trouble.Objectif. Cet article présente le processus de conception d’un questionnaire visant à éva­luer le fonctionnement au...

Attitudes toward immigrants in European societies: editorial

Moshe Semyonov & Eldad Davidov

Sensitivity and fragmentation calibration of the time-of-flight mass spectrometer RTOF on board ESA's Rosetta mission

Léna Le Roy, Henri Rème, J. Hunter Waite, Annette Jäckel, Björn Fiethe, Axel Korth, Peter Wurz, Kathrin Altwegg, Martin Rubin, Sébastien Gasc & Urs Mall
The European Space Agency's Rosetta spacecraft, with the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) onboard, has been following and observing comet 67P/Churyumov-Gerasimenko since summer 2014. Prior to this period, and due to a technical failure also during this period, optimization and calibration campaigns have been conducted on ground with the Reflectron-type Time Of Flight (RTOF) mass spectrometer as a preparatory work for the analysis of data recorded during the science phase of...

European guideline for the diagnosis and treatment of insomnia.

Oana-Claudia Deleanu, Chiara Baglioni, Damien Leger, Markus Jansson-Fröjmark, Liborio Parrino, Christoph Nissen, Marielle Zoetmulder, Colin A Espie, Kai Spiegelhalder, Poul J Jennum, Adam Wichniak, Jason G Ellis, Dieter Riemann, Diego Garcia-Borreguero, Elisabeth Hertenstein, Dirk Pevernagie, Erna S Arnardottir, Irina Zavalko, Michaela Gjerstad, Hans-Günter Weeß, Tiina Paunio, Claudio Bassetti, Barbara Strazisar, Leja Dolenc Groselj, Marta Gonçalves … & Johan Verbraecken
This European guideline for the diagnosis and treatment of insomnia was developed by a task force of the European Sleep Research Society, with the aim of providing clinical recommendations for the management of adult patients with insomnia. The guideline is based on a systematic review of relevant meta-analyses published till June 2016. The target audience for this guideline includes all clinicians involved in the management of insomnia, and the target patient population includes adults with...

Epistaxis in anticoagulated patients: Fewer hospital admissions and shorter hospital stays on rivaroxaban compared to phenprocoumon.

Wolf Hautz, Meret Ricklin, G Krummrey, Michael Nagler, K Hegazy, Thomas Sauter, U Borner & Aristomenis Exadaktylos
OBJECTIVES Treatment of epistaxis in patients on anticoagulants is challenging and associated with higher admission rates and longer hospital stays compared with patients without anticoagulation. However, there is little information about epistaxis in patients taking new direct oral anticoagulants such as rivaroxaban compared with patients on traditional vitamin K antagonists such as phenprocoumon. DESIGN Retrospective cohort study. SETTING The study was conducted at the emergency department of the University Hospital Inselspital, Bern, Switzerland. PARTICIPANTS All...

Sleep-related movement disorders and disturbances of motor control.

Panagiotis Bargiotas & Claudio Bassetti
PURPOSE OF REVIEW Review of the literature pertaining to clinical presentation, classification, epidemiology, pathophysiology, diagnosis, and treatment of sleep-related movement disorders and disturbances of motor control. RECENT FINDINGS Sleep-related movement disorders and disturbances of motor control are typically characterized by positive motor symptoms and are often associated with sleep disturbances and consequent daytime symptoms (e.g. fatigue, sleepiness). They often represent the first or main manifestation of underlying disorders of the central nervous system, which require...

Global Modern Charcoal Dataset (GMCD): A tool for exploring proxy-fire linkages and spatial patterns of biomass burning

Xu Yue, Donna Hawthorne, Natalie Kehrwald, Esther N. Githumbi, Olivier Blarquez, Anne-Laure Daniau, Rob Marchant, Yongming Han, Daniele Colombaroli, Stijn Hantson, Julie C. Aleman, Colin J. Courtney Mustaphi, Christopher Carcaillet, Boris Vannière, Rebecca M. Muriuki, Brian Magi, Mitchell Power, Jennifer R. Marlon & Ayodele Ogunkoya
Progresses in reconstructing Earth's history of biomass burning has motivated the development of a modern charcoal dataset covering the last decades through a community-based initiative called the Global Modern Charcoal Dataset (GMCD). As the frequency, intensity and spatial scale of fires are predicted to increase regionally and globally in conjunction with changing climate, anthropogenic activities and land-use patterns, there is an increasing need to further understand, calibrate and interrogate recent and past fire regimes as...

Impact of early versus deferred antiretroviral therapy on estimated glomerular filtration rate in HIV-positive individuals in the START trial.

Hansjakob Furrer, Amanda Clarke, Anchalee Avihingsanon, Matti Ristola, Amanda Mocroft, Lene Ryom-Nielson, Shweta Sharma, Elzbieta Bakowska, Christina Wyatt, Waldo Belloso, Jonathan Ross, Michael Ross, Gregory M Lucas, Charurut Somboonwit, Amit C Achhra & Mohammed Rassool
BACKGROUND Both untreated HIV infection and antiretroviral therapy (ART) have been associated with worsening kidney function. The impact of earlier ART initiation on kidney function has not been studied. METHODS The START trial was a randomized comparison of immediate versus deferred ART initiation among HIV+ persons with CD4+ counts >500 cells/mm(3). Serum creatinine and urine dipstick protein were measured at baseline, months 1, 4, 8, 12, and annually thereafter. We compared the two arms for...

Optical In-Situ Monitor – A Step towards European Space-Based Debris Observations

T. Flohrer, Lionel Séraphin Charles Métrailler, N. Lievre, L. Ferreira, J. Utzmann & G. Vives

Requirements for observation scenarios to maintain a catalogue of space debris objects in geosynchronous region

Thomas Schildknecht, A. Hinze & H. Fiedler
Optical observations for space debris in the geosynchronous region have been performed for many years. During this time, observation strategies, processing tech- niques and cataloguing approaches were successfully developed. The importance of protecting this orbital region from space debris requires continuous surveying and monitoring in order to support collision avoidance operations. Further observations of the objects, providing information for orbit improvement calculations, are helping to maintain high accuracy ephemeris of the catalogued objects. This paper...

Investors’ Risk Perceptions of Structured Financial Products with Worst-of Payout Characteristics

Martin Wallmeier, Claude Messner & Alexis H. Kunz
We conduct an experiment to investigate how investors assess the risk of Reverse Convertibles that link the payout to the worst performing stock of a pool of underlying assets. Based on theory from psychology, we conjecture that investors’ risk perception can be systematically biased downwards via the strategic selection and composition of the underlying assets. We predict and find that adding relatively safe assets to a risky underlying asset decreases perceived investment risk despite the...

The Use of a Single Budget or Separate Budgets for Planning and Performance Evaluation

Markus Christopher Arnold & Martin Artz
Budgeting has different functions in the firm that are not necessarily congruent with each other but conflict. Specifically, in many firms, budgets are simultaneously set and used for both operative planning and performance evaluation. Although prior literature recommends using different budget levels for different purposes to resolve potential conflicts between these functions, empirical evidence indicates that the majority of firms use a single budget level for planning and performance evaluation. To examine the questions of...

Anti-TNF Treatment for Extraintestinal Manifestations of Inflammatory Bowel Disease in the Swiss IBD Cohort Study.

Stephan R Vavricka, Pierre Michetti, Henriette Heinrich, Alain M Schoepfer, Swiss IBD Cohort Study Group, Michael Scharl, Ekaterina Safroneeva, Martin Gubler, Christine N Manser, Gerhard Rogler, Benjamin Misselwitz, Alex Straumann, Jonas Zeitz, Thomas Greuter, Pascal Juillerat, Nicolas Fournier, Frank Seibold, Muriel Spoerri, Florian Froehlich, Luc Biedermann, Marijana Protic, Claudine Gantenbein & Raja Affendi Raja Ali
BACKGROUND Extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) are frequently observed. Little is known about the efficacy of anti-tumor necrosis factor (TNF) in EIM management. We assessed the effect of 3 anti-TNF agents (infliximab, adalimumab, and certolizumab pegol) on EIM evolution. METHODS Data on 1249 patients from the Swiss IBD Cohort Study (SIBDCS) were analyzed. All EIMs were diagnosed by relevant specialists. Response was classified into improvement, stable disease, and clinical worsening...

Frequency, Timing, and Impact of Access-Site and Non-Access-Site Bleeding on Mortality Among Patients Undergoing Transcatheter Aortic Valve Replacement.

Fabien Praz, Raffaele Piccolo, Bettina Langhammer, Alan Haynes, Stephan Windecker, Eva Roost, Marco Valgimigli, Anna Franzone, Jonas Lanz, Lorenz Räber, Masahiko Asami, Stefan Stortecky & Thomas Pilgrim
OBJECTIVES The aim of this study was to examine the frequency, timing, and association of access-site and non-access-site bleeding with mortality in the setting of transcatheter aortic valve replacement (TAVR) during long-term follow-up. BACKGROUND Bleeding is frequent and associated with impaired prognosis in patients undergoing TAVR. It is currently unknown whether the site of bleeding differentially influences the outcomes of TAVR patients. METHODS In total, 926 consecutive patients undergoing TAVR from 2007 through 2014 were...

Archaeology of the Alpine Space. Research on the foothills, valley systems and high mountain landscapes.

Julian Laabs, Mirco Brunner & Albert Hafner
Археологія альпійського простору. Дослідження передгір’їв, долинних систем та високогірних ландшафтів Альп В даній статті наводяться приклади ландшафтних археологічних досліджень в альпійському регіональному контексті. Як навколо, так і в самих Європейських Альпах ландшафти відзначаються великою різноманітністю. Найбільш істотні ландшафтні відмінності спостерігаються на висотах, що мають відмітки від 400 до 3000 ібільше метрів над рівнем моря. Основними топографічними ознаками регіону являються горбисті альпійські передгір’я, широкі внутрішні долини, що заходять далеко в самі Альпи та високогірні зони, які...

Prevention and Care of Hepatitis B in Senegal; Awareness and Attitudes of Medical Practitioners.

Antoine Jaquet, Fatou Fall, Ndeye Mery Dia, Judicaël Tine, François Dabis, Mouhamadou Baïla Diallo, Noel M Manga, Moussa Seydi & Gilles Wandeler
In highly endemic settings for hepatitis B virus (HBV) infection such as Senegal, access to HBV prevention and care is rapidly evolving. In this context, all medical practitioners should have baseline knowledge on HBV infection and promote access to vaccination, screening, and care. A knowledge and attitudes survey on HBV infection was conducted among a randomly selected sample of medical practitioners in Senegal. Participants were asked to fill-out a questionnaire on the HBV epidemiology, prevention,...

Workshop on \"Kiranti Culture in Contemporary Nepal\", Vienna, 4-5 April 2014

Marion Wettstein
Workshop Report

Caplacizumab reduces the frequency of major thromboembolic events, exacerbations, and death in patients with acquired thrombotic thrombocytopenic purpura.

Johanna Anna Kremer Hovinga, F Peyvandi, P Knöbl, F Callewaert, H De Winter, K De Beuf, S Cataland, M Scully & R K Zeldin
BACKGROUND Acquired thrombotic thrombocytopenic purpura (aTTP) is a life-threatening autoimmune thrombotic microangiopathy. In spite of treatment with plasma exchange and immunosuppression, patients remain at risk for thrombotic complications, exacerbations and death. In the Phase II TITAN study, treatment with caplacizumab, an anti-vWF Nanobody(®) , was shown to reduce the time to confirmed platelet count normalization and exacerbations during treatment. OBJECTIVE The clinical benefit of caplacizumab was further investigated in a post-hoc analysis of the incidence...

Health Effects of Overweight and Obesity in 195 Countries- Correspondence.

Arnaud Chiolero, Jude Gedeon & Pascal Bovet

Decrease of ethyl glucuronide concentrations in hair after exposure to chlorinated swimming pool water.

Susanne Nussbaumer, Marc Luginbühl & Wolfgang Weinmann
The direct alcohol marker ethyl glucuronide (EtG) is widely used for the assessment of alcohol consumption behavior and abstinence monitoring by hair analysis. We investigated the influence of chlorinated swimming pool water on EtG concentrations in hair in comparison to deionized water (Milli-Q) containing no chlorine. EtG concentrations were measured with a validated online-SPE-LC-MS/MS method. EtG positive hair samples were obtained from three regular drinkers and incubated for 0, 2, 4, 6, 8, and 10...

Impact energy of everyday items used for assault

Lea Siegenthaler, Beat P. Kneubühl, Christian Jackowski & Florian D Sprenger
Blunt force is a frequently used type of violence especially because it can be performed with basically every object of our daily lives or with bare hands or feet. The injuries and medical consequences have been widely examined, whereas the forces and especially the energies acting on impact have rarely been analyzed. The aim of the present study is to provide the impact energy and its ranges of four longish everyday items with different characteristics...

Rapid Characterization of Geosynchronous Space Debris with 5-color Near-IR Photometry

A.D. Block, Thomas Schildknecht, K. Rockowitz, H. Alyson Ford, V. Reddy & E. Pearce
The characterization of deep space debris has posed a significant challenge in SSA. To be most operationally effective, characterization must be performed quickly and under non-ideal operational conditions, generally using non-resolved techniques. The use of multi-color photometry and the resultant color indices in the near and short- wave IR offer the potential to rapidly discriminate between debris and intact space objects such as rocket bodies and satellites. Specifically, the color indices surrounding the near-IR Z...

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