1,187,481 Works

Neuroimaging Explanations of Age-Related Differences in Task Performance

Jason Steffener, Daniel James Barulli, Christian G. Habeck & Yaakov Stern
Advancing age affects both cognitive performance and functional brain activity and interpretation of these effects has led to a variety of conceptual research models without always explicitly linking the two effects. However, to best understand the multifaceted effects of advancing age, age differences in functional brain activity need to be explicitly tied to the cognitive task performance. This work hypothesized that age-related differences in task performance are partially explained by age-related differences in functional brain...

Social Cognition in Alzheimer's Disease: A Separate Construct Contributing to Dependence

Stephanie Cosentino, Laura B. Zahodne, Jason Brandt, Deborah Blacker, Marilyn Albert, Bruno Dubois & Yaakov Stern
The extent to which social cognitive changes reflect a discrete constellation of symptoms dissociable from general cognitive changes in Alzheimer's disease (AD) is unclear. Moreover, whether social cognitive symptoms contribute to disease severity and progression is unknown. The current multicenter study investigated cross-sectional and longitudinal associations between social cognition measured with six items from the Blessed Dementia Rating Scale, general cognition, and dependence in 517 participants with probable AD. Participants were monitored every 6 months...

Unique Ion Filter: A data reduction tool for GC/MS data preprocessing prior to chemometric analysis

Adutwum, Lawrence A.; Harynuk, James

Functional Status in the Young-Old: Establishing a Working Prototype of an Extended-Instrumental Activities of Daily Living Scale

Robert A. Fieo, Jennifer J. Manly, Nicole Schupf & Yaakov Stern
BACKGROUND: Instrumental activities of daily living (IADLs) exhibit strong predictive power for the presence of dementia and mild cognitive impairment. However, IADLs are often less effective in younger cohorts or in healthy community-dwelling samples, presenting with large ceiling effects. This study aimed to construct an IADL scale with an extended range. An effort was made to incorporate leisure activity tasks that were more stimulating, and potentially more challenging, into a set of traditional IADLs. METHODS:...

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Made Wijaya (Michael White)

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